Peer-reviewed: antimicrobial peptide systems characterized in Chinook salmon

A six-month commercial trial in Chinook salmon (Oncorhynchus tshawytscha), published in the Journal of Fish Biology (2026, Marcoli et al.), presents the first full characterization of the HAMP and LEAP2 antimicrobial peptide systems in this species.

Fish receiving NatControl^® showed increased expression of HAMP (hepcidin) in head kidney, spleen, liver, gills and skin, while LEAP2 paralogues rose in liver, kidney, gills and skin. These tissues form the front line of the fish’s natural defenses.

Importantly for producers, the trial found no negative effect on growth or survival, addressing a common operational concern about immune-modulating feed additives.

“Independent research shows that NatControl can improve the fish’s natural immune preparedness at the molecular level.”

Dr. Juan Hancke · Chief Scientific Officer, HP Ingredients

The industry publication Fish Farming Expert covered the study, so the findings also have independent, third-party visibility.